Our goal to understand how the eukaryotic genome is packaged with histones into chromatin and how chromatin is propagated, expressed, and those transcripts spliced into mature gene transcripts.
To improve our basic understanding of biology, human disease, and also to develop new therapeutic approaches, we aim to understand how these processes work and how they are regulated by the cell. Our studies are critically important for understanding diseases such as lung cancer and leukemia, and have wide-ranging implications for human development and neuroscience. Our current primary research interests are currently in the basic biochemistry, cell biology, and cancer biology of:
Protein Arginine Methyltransferases (PRMTs1-9), their protein substrates, and the "readers" of methylarginine
Histone chaperone proteins (NPM1, NPM2, and NAP1) and structural and molecular mechanisms of their intrinsically disordered regions
Chaperone post-translational glutamylation and deglutamylation by the TTLL and CCP protein families